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Treatment Results

Reducing inflammatory acne lesions can decrease the risk of scarring.2

OSCAR Study Treatment Results

IGA 4 severe acne before Epiduo Forte gel treatment (baseline). IGA 2 mild acne after Epiduo Forte gel treatment for 12 Weeks.

Baseline: IGA 4
Severe Acne

Week 12: IGA 2
Mild Acne

OSCAR Study Design

A two-phase, randomized, multicenter, investigator-blinded, vehicle-controlled trial evaluating once-daily Epiduo® Forte Gel in moderate to severe acne subjects 16 to 35 years old with a clinical diagnosis of moderate to severe acne vulgaris on the face (defined by IGA score of 3 or 4, with the same score on both sides); a minimum of 25 inflammatory lesions (papules and pustules) in total, with at least 10 on each side (excluding the nose); no more than 2 acne nodules (≥1 cm); and ≥10 atrophic acne scars in total (>2 mm), excluding the nose. Phase 1 was a split-face, 24-week, investigator-blinded, vehicle-controlled study (n=67) at 8 visits (baseline, Weeks 1, 4, 8, 12, 16, 20, and 24). Phase 2 was a whole-face, open-label study in which select subjects (investigator and subject agreement to continue) continued treatment for an additional 24 weeks with 2 visits (weeks 36 and 48). Primary endpoint was scar count.4

Important Safety Information

Indication: Epiduo® Forte (adapalene and benzoyl peroxide) Gel, 0.3%/2.5% is indicated for the topical treatment of acne vulgaris. Adverse Events: In the pivotal study, the most commonly reported adverse reactions (≥1%) in patients treated with Epiduo® Forte Gel were skin irritation, eczema, atopic dermatitis and skin burning sensation. Warnings/Precautions: Patients using Epiduo® Forte Gel should avoid exposure to sunlight and sunlamps and wear sunscreen when sun exposure cannot be avoided. Erythema, scaling, dryness, stinging/burning, irritant and allergic contact dermatitis may occur with use of Epiduo® Forte Gel and may necessitate discontinuation. When applying Epiduo® Forte Gel, care should be taken to avoid the eyes, lips and mucous membranes.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‐800‐FDA‐1088.

  1. Epiduo® Forte Gel Clinical Study Report (SRE 18240). Data on file. Galderma Laboratories, L.P.
  2. Tan J, Bourdes V, Bissonnette R, et al. Prospective study of pathogenesis of atrophic acne scars and role of macular erythema. J Drugs Dermatol. 2017;16(6):567-573.
  3. Del Rosso JQ, Stein Gold L, Marchese Johnson S, et al. Efficacy and safety of adapalene 0.3%/benzoyl peroxide 2.5% gel plus oral doxycycline in subjects with severe inflammatory acne who are candidates for oral isotretinoin. J Drugs Dermatol. 2018;17(3):264-273.
  4. Epiduo® Forte Gel Clinical Study Report (SPR 105061 ). Data on file. Galderma Laboratories, L.P.
  5. DuBois J, Ong GCW, Petkar G, et al. Patient-reported outcomes in acne patients with skin of color using adapalene 0.3%-benzoyl peroxide 2.5%: a prospective real-world study. J Drugs Dermatol. 2019;18(6):514-520.
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Program Details For All Savings Offers

Epiduo® Forte (adapalene and benzoyl peroxide) Gel, 0.3%/2.5%

The Galderma® CareConnect Program is brought to you by Galderma Laboratories, L.P. The Patient Savings Card provides savings on out‑of‑pocket expenses for up to a 30‑day supply of included Galderma products. If you have valid prescriptions for more than one Galderma product, the copay expense and savings apply to each product. You may use the Patient Savings Card once every 30 days, depending on when you last received a 30‑day supply of each Galderma product. Use of the Patient Savings Card does not obligate you to use or to continue using any Galderma product. You may use the Patient Savings Card at any participating pharmacy located in the United States.

The Galderma CareConnect Program Patient Savings Card may not be combined with any savings, discount, free trial, or other similar offer for the same prescription. The Patient Savings Card is not transferable and is void if reproduced. The Patient Savings Card is not health insurance. Limit one (1) Patient Savings Card per patient. The Galderma CareConnect Program Patient Savings Card has no cash value and will not be accepted outside of participating pharmacies in the United States. Please visit Galderma’s website for our privacy practices. Galderma reserves the right to revoke or amend this offer without notice at any time and to deny payment for noncompliance with the terms of this offer.

Use of this Patient Savings Card is subject to applicable state and federal law, and is void where prohibited by law, rule or regulation. In the event an AB rated generic equivalent product becomes available for one of the Galderma products covered by this Patient Savings Card, this offer will become void in Massachusetts with respect to that Galderma product.

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  • You have a valid prescription for the Galderma product your copay and the savings apply to;
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