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The #1-Prescribed Branded Topical Acne Treatment1

Properties of Epiduo Forte Gel Can Make a Difference

The powerful combination of adapalene and benzoyl peroxide (BPO) targets 3 out of 4 causative factors of acne.2

Image of Adapalene and BPO in complementary action.

Adapalene 0.3%

  • Inhibits release of proinflammatory mediators3
  • Promotes keratinization and regulates cell turnover3,4
  • Has low potential for irritation3

BPO 2.5%

  • Acts as an effective bacteriocide—without promoting resistance5
  • Kills up to 99% of P acnes, a common precursor to inflammation6

Epiduo Forte Gel contains the highest strength of adapalene available for your patients7

Simulgel - A Unique Delivery System

The effective combination of adapalene and BPO with the proven technology of the simulgel delivery system does the following:

Image of simulgel containing adapalene and BPO.
  • Allows for homogeneous dispersion of acting ingredients8
  • Not sensitive to pH variations8
  • Maintains suspension of both components via a polymer network8
  • Stabilizes adapalene and BPO and optimizes tolerability8
  • Non-greasy and occlusive properties8

Simulgel is a unique delivery system containing two humectants and two emollients for an ideal formulation.8

Bottle of Epiduo® Forte Gel.

How to Use

These application instructions will help patients correctly apply Epiduo Forte Gel to their face.

  1. Wash the face with a gentle, non-soap cleanser like CETAPHIL® Pro Oil Removing Foam Wash.
  2. Dry without scrubbing, using a soft towel.
  3. Spread a pea-sized amount of Epiduo Forte Gel in a thin layer over the affected areas of the face. Avoid eyes, lips and nostrils where skin is thin like the inside of your nose.
  4. Apply a gentle moisturizer, preferably one with SPF protection like CETAPHIL® Pro Oil Absorbing Moisturizer with Sunscreen Broad Spectrum SPF 30.

Remind patients to wash their hands after applying Epiduo Forte Gel, and to wait for the gel to dry completely before getting dressed.

Routine Matters. myForte Can Help!

Routines build positive habits and help patients stick to their treatment. myForte is a free app where patients can keep track of their progress between visits and set reminders that help make Epiduo Forte Gel part of their daily skincare routine.

Learn More

Track Your Acne Progress with the MyForte app.

Important Safety Information

Indication: Epiduo® Forte (adapalene and benzoyl peroxide) Gel, 0.3%/2.5% is indicated for the topical treatment of acne vulgaris. Adverse Events: In the pivotal study, the most commonly reported adverse reactions (≥1%) in patients treated with Epiduo® Forte Gel were skin irritation, eczema, atopic dermatitis and skin burning sensation. Warnings/Precautions: Patients using Epiduo® Forte Gel should avoid exposure to sunlight and sunlamps and wear sunscreen when sun exposure cannot be avoided. Erythema, scaling, dryness, stinging/burning, irritant and allergic contact dermatitis may occur with use of Epiduo® Forte Gel and may necessitate discontinuation. When applying Epiduo® Forte Gel, care should be taken to avoid the eyes, lips and mucous membranes.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1‐800‐FDA‐1088.

  1. According to data from Symphony Health Solutions, Pharmaceutical Audit Suite, Retail Audit, July 2019.
  2. Alexis AF, Cook-Bolden FE, York JP. Adapalene/benzoyl peroxide gel in 0.3%/2.5%: a safe and effective acne therapy in all skin prototypes. J Drugs Dermatol. 2017;16(6):574-581.
  3. Leyden J. Topical treatment of acne vulgaris: retinoids and cutaneous irritation. J Am Acad Dermatol. 1998;38(4):S1-S4.
  4. Thielitz A, Sidou F, Gollnick H. Control of microcomedone formation throughout a maintenance treatment with adapalene gel, 0.1%. J Eur Acad Dermatol Venereol. 2007;21(6):747-753.
  5. Tucker R, Walton S. The role of benzoyl peroxide in the management of acne vulgaris. Pharm J. 2007;279:48-53.
  6. Mills OH, Jr, Kligman AM, Pochi P, Comite H. Comparing 2.5%, 5%, and 10% benzoyl peroxide on inflammatory acne vulgaris. Int J Dermatol. 1986;25(10):664-667.
  7. Leyden J, Stein-Gold L, Weiss J. Why topical retinoids are mainstay of therapy for acne. Dermatol Ther. 2017;7(3):293-304.
  8. Data on file. Galderma Laboratories, L.P.
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Program Details For All Savings Offers

Epiduo® Forte (adapalene and benzoyl peroxide) Gel, 0.3%/2.5%

The Galderma® CareConnect Program is brought to you by Galderma Laboratories, L.P. The Patient Savings Card provides savings on out‑of‑pocket expenses for up to a 30‑day supply of included Galderma products. If you have valid prescriptions for more than one Galderma product, the copay expense and savings apply to each product. You may use the Patient Savings Card once every 30 days, depending on when you last received a 30‑day supply of each Galderma product. Use of the Patient Savings Card does not obligate you to use or to continue using any Galderma product. You may use the Patient Savings Card at any participating pharmacy located in the United States.

The Galderma CareConnect Program Patient Savings Card may not be combined with any savings, discount, free trial, or other similar offer for the same prescription. The Patient Savings Card is not transferable and is void if reproduced. The Patient Savings Card is not health insurance. Limit one (1) Patient Savings Card per patient. The Galderma CareConnect Program Patient Savings Card has no cash value and will not be accepted outside of participating pharmacies in the United States. Please visit Galderma’s website for our privacy practices. Galderma reserves the right to revoke or amend this offer without notice at any time and to deny payment for noncompliance with the terms of this offer.

Use of this Patient Savings Card is subject to applicable state and federal law, and is void where prohibited by law, rule or regulation. In the event an AB rated generic equivalent product becomes available for one of the Galderma products covered by this Patient Savings Card, this offer will become void in Massachusetts with respect to that Galderma product.

By using the Galderma CareConnect Program Patient Savings Card, you acknowledge that you currently meet the following eligibility criteria:

  • You have a valid prescription for the Galderma product your copay and the savings apply to;
  • You have no insurance or are subject to a private insurance copay Requirement for your prescription;
  • You are not enrolled in Medicare Part D, Medicaid, Medigap, VA, DOD, Tricare, or any other government-run or government sponsored health care program with a pharmacy benefit;
  • You are at least 18 years old; and
  • You reside in the United States.